Transcription factor binding site detection through position cross-mutual information variability analysis

摘要

Regulatory sequence detection is a fundamental challenge in computational biology. One key process in protein\udsynthesis starts with the binding of the transcription factor to its binding site. Different sites can show binding to the same\udfactor. This variability found in binding sequences increases the difficulty of their detection using computational algorithms. In\udthis manuscript, a method for the detection of binding sites is proposed, based on the correlation between binding sequence\udpositions through information theoretical measures. Efficiency values of the method are reported in the form of Receiver\udOperating Characteristic curves on the detection of different transcription factors of the Saccharomyces cerevisiae organism.\udWe compare our results with other known motif detection Motif Discovery scan (MDscan).